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The inhibition or reversal of tachyphylaxis and fade by both ascorbate [70,71,72,73,74,75] and opioids [65,76,77] is mediated by increased cGMP production and concomitant inhibition of the G protein-mediated phosphorylation that down-regulates the receptor

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Alternatives and Complementary Treatments Even when surgery is the central treatment for resectable disease, it is almost never used alone