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The observation that, at the glutamatergic PSD, Shank proteins may contribute to assembling the NMDAR/PSD-95/nitric oxide synthase-1 (NOS1) complex with the guanylate kinase-associated protein (GKAP) adaptor protein is relevant in terms of antipsychotics’ impact on oxidative pathways [266]

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The effects of SAM-e supplementation were observed in review studies conducted during varying time lengths, generally between 2 and 12 weeks, and given at 200-3200 mg doses