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Negative binomial regression models followed by post hoc comparisons of estimated marginal means using the emmeans 68 package in R with Tukey adjustment for multiple comparisons were used to evaluate significant differences in CR between stage 1, stage 2 and stage 3 in each of the following: CD incidence, UC incidence, CD prevalence and UC prevalence

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verify clarity before use Dosage Guidelines Typical adult regimen (per package insert): 100 mcg IM/SC daily for 6–7 days Then 100 mcg every other day for 2–3 weeks Maintenance with 100 mcg IM/SC monthly for life Adjust based on patient response and serum vitamin B₁₂ levels Clinical Applications Used to correct symptomatic or laboratory-confirmed B₁₂ deficiency, where rapid repletion is needed or oral supplementation is unreliable