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The presence of MGMT is an important reason for the resistance of GBMs to TMZ ( ROS are reactive substances produced by oxygen reduction, including hydrogen peroxide (H 2 O 2 ), organic hydroperoxide (ROOH), singlet oxygen ( 1 O 2 ), ozone (O 3 ), superoxide anion (O 2 ˙‾ ), hydroxyl radical (OH·), and peroxyl radical (ROO·) ( In gliomas, appropriate amounts of ROS can activate growth-related signalling pathways, induce DNA mutations, and promote invasion and metastasis ( 2 ROS production and antioxidant defence systems ROS production is caused by exogenous environmental stimuli or endogenous metabolism