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This PEGylation process helps to prevent rapid clearance by the body’s reticuloendothelial system (RES) [33], which would otherwise reduce the effectiveness of the treatment by shortening the time these nanomaterials remain in the bloodstream [34]

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5), although there was a low actual incidence of recovery: greater than 0.1 at 12 months, greater than 0.2 at 24 months, and greater than 0.3 at 36 and 60 months