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This antioxidant system is essential for normal cellular and organismal functions, as evident by the observations that either Trx knockout or TrxR knockout mice are embryonic lethal.72, 73, 74 The Trx system exerts its antioxidant activity mainly by transferring electrons to thioredoxin peroxidases (Prxs), which use a pair of SH groups as reducing equivalents to reduce peroxides, such as H 2 O 2 , ONOO − and ROOH