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MT genes were significantly upregulated upon differentiation from osteoclast precursors to mature osteoclasts in response to receptor activators of nuclear factor-κB (NF-κB) ligand (RANKL) stimulation, and MT3 expression was particularly pronounced in mature osteoclasts among MT genes

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Tingling in the first two to four weeks, alongside grip weakness or night-time wrist pain, is a signal to drop the dose immediately