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Despite the obvious consequences of the functional B2 deficiency in the metabolism of B12, the majority of authors do not seem cognizant of this (Obeid etal, 2015), and seem to believe that B12 deficiency only occurs due to low intake of the vitamin, rather than ineffective processing, and are unaware of the phenomenon of Paradoxical B12 deficiency

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Partly due to this realization, more and more research over the past few years has focused on finding ways to lengthen the average healthspan.2 Besides the positive impacts of lifestyle modifications, like eating right and exercising, some experts are investigating pharmacological or supplemental avenues