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Smaller, denser LDLs are significantly more atherogenic for two reasons: they are much more susceptible to oxidation, 15-17 and they pass from the bloodstream into the blood vessel wall much more efficiently than large, buoyant LDL particles

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All downstream bioinformatic analyses were performed using Omicsmart, a dynamic, real-time interactive online platform for data analysis ( MESA enrichment analysis of metabolic pathways Metabolite Set Enrichment Analysis (MSEA) was conducted using the MetaboAnalyst software (v6.0)