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Elevated levels of NAD + have been shown to suppress the progression of MASLD, while in ALD, chronic ethanol oxidation depletes hepatic NAD +

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Sclerosing cholangitis can be divided into primary sclerosing cholangitis (PSC) of unidentified etiology and secondary sclerosing cholangitis caused by various identifiable etiologies, including immunoglobulin G4-related sclerosing cholangitis (IgG4-SC), recurrent pyogenic cholangitis (RPC), ischemic cholangitis, acquired immunodeficiency syndrome (AIDS)-related cholangitis, and eosinophilic cholangitis