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Summary Keywords ferroptosis, blood brain barrier, iron accumulation, lipid peroxidation, tight junctions Citation Chen X, Pang X, Yeo AJ, Xie S, Xiang M, Shi B, Yu G and Li C (2022) The Molecular Mechanisms of Ferroptosis and Its Role in Blood-Brain Barrier Dysfunction

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The accumulation of fat can lead to a dysfunction in the biosynthesis of L-carnitine (Figure 1) in the liver thus inducing a negative feedback loop, whereby less L-carnitine is produced which leads to enhanced impairment of fatty acid oxidation re-enforcing fatty liver disease