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Mechanisms of Action Although the mechanisms through which n -3 polyunsaturated fatty acids improve glycemic control are not currently well understood [204], in vivo studies on animal models described some potential processes including (a) enhancement of insulin sensitivity in the liver [205] through lowered lipogenesis and increased fatty acid oxidation [206,207], (b) insulin sensitizing effect through the increase adipocytokines release [208] and (c) avoidance of insulin resistance by both direct [209] and indirect [210,211] anti-inflammatory actions

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In agreement with this, the ability of PA to protect cells against oxidative stress has been associated with inhibited ROS generation, increased GSH levels, and decreased lipid peroxidation (MDA), as shown in several studies ( An increased ROS level can directly or indirectly control the SIRT-1 enzyme ( SIRT-1 has a crucial role in modulating multiple physiological processes