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4.2 Cognitive impairment after stroke Pathophysiology of cognitive impairment following ischemic stroke involves damage to the cortex and hippocampus due to direct ischemia or secondary degeneration, initiating chronic neuroinflammation and blood-brain barrier breakdown, and ultimately leading to synaptic loss and neuron death, and also white matter injury (38, 89)

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If you are experiencing severe or persistent diarrhea at a given dose level, extending that dose period from 4 weeks to 6 or even 8 weeks before escalating is a legitimate strategy