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doi: 10.3389/fimmu.2022.986847 Received 05 July 2022 Accepted 08 September 2022 Published 23 September 2022 Volume 13 - 2022 Edited by Keiji Hirota, Kyoto University, Japan Reviewed by Michihito Kono, Hokkaido University, Japan

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Mechanistically, the glutamate-induced oxidative cytotoxicity is mediated via two different pathways, namely, the receptor-mediated excitotoxicity and the non-receptor-mediated oxidative cytotoxicity 33,34,35,36