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This is why most therapeutic peptides approved for systemic use (insulin, GLP-1 agonists, etc.) are injectable or have required extensive chemical modification to survive oral delivery

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A prominent line of reasoning about the pathogenesis of schizophrenia, for instance, is that the schizophrenic brain is constitutively vulnerable to oxidative insults and that typically benign oxidative challenges can cause changes to the schizophrenic brain that manifest as symptoms [45]