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This was also true for RAMP1 KO and RAMP3 KO mice who exhibited a decrease in cagrilintide-induced cFos positive neurons compared to WT mice

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Furthermore, hemorrhagic transformation was also lower in frequency for patients who started IV thrombolysis between 1200 and 1800 h compared to those who received treatment between 0000 and 0600 h (Marler et al., 1989)