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Supporting this pathway, fecal samples from stress-induced depression models to healthy mice induces hippocampal neurogenesis deficits and neuroinflammation, whereas these effects are abolished after vagotomy (Siopi et al., 2023)

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Although LDR-induced ROS in humans has not been that well-studied, individuals exposed to LDR (0.004 Gy/year) showed increased H 2 O 2 production and antioxidant expression, and their cells showed susceptibility to apoptosis (Russo et al., 2012)