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Other reports have emerged ASX to be immunostimulatory: in vitro studies on human lymphocytes have also shown that ASX increases immunoglobulin production in response to T cell-dependent stimuli, as well as increased natural NK cell cytotoxic activity, highlighting the importance of NK cell regulation in serving as an immunosurveillance system against tumors and virus-infected cells [217,218,219]

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However, posttreatment with anti-Gr1 did not protect [117], and pretreatment with anti-Gr1 caused a preconditioning effect with substantial activation of metallothionein 1 and 2 proteins [118]