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Data source and data preprocessing The gene-expression profile and clinical data of various breast cancer cell lines and patient cohorts from 16 eligible datasets, including tamoxifen-resistant and parental tamoxifen-sensitive MCF7 (GSE67916) and T47D (GSE125738) cell lines, fulvestrant-resistant and parental fulvestrant-sensitive MCF7 (GSE74391 and GSE85536) and T47D (GSE85536) cell lines, parental and lapatinib-induced persister BT474 cell lines (GSE84896), the Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohorts, a Chinese breast cancer cohort (GSE20685), primary breast cancers before and after neoadjuvant tamoxifen therapy (GSE147271), breast cancers from postmenopausal patients before and after neoadjuvant letrozole therapy (GSE20181), breast cancers in different subtypes before receiving different neoadjuvant therapy regimens targeting diverse biology from the I-SPY2 platform trial (GSE181574, GSE194040, and GSE173839), and breast cancers before neoadjuvant chemotherapy (GSE41998, GSE163882, and GSE25066), were collected from the publicly available Gene Expression Omnibus (GEO), TCGA, and METABRIC databases
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Immediately discontinue use and consult your doctor if you experience any adverse reaction to this product.
